Protect your tree and plant investment! Mix 1 tablespoon of dry concentrate per 2 1/2 gallons of water to your apple and pear trees at the beginning of blossom-time to control bacterial issues like fire blight. Repeat applications every 3-4 days until bloom time ends. Apply an additional spray 5-7 days after blooms end, when weather conditions favor the spread of diseases such as fire blight, bacterial wilt, stem rot, leaf spot, and crown gall.. Do not apply when fruit is visible. May also be used on roses. Follow product label for more detailed instructions.